A Transformative Lysing Technology - Lyse any bacteria, cell, virus in 30 s in one step


Recent Papers which have utilized the Lyse-It Technology

1. Santaus, T., Greenberg, K., Suri, P., and Geddes, C.D. (2019). Elucidation of a non-thermal mechanism for DNA/RNA fragmentation and protein degradation when using Lyse-It. PLOS ONE, 14(12): e0225475.

2. Santaus, T., Zhang, F., Li, S., Stine, O.C., and Geddes, C.D. (2019). Effects of Lyse-It on endonuclease fragmentation, function and activity. PLOS ONE, 14(9): e0223008. 

3. Santaus, T., Shan, L., Saha, L., Chen, W.H., Bhagat, S., Stine, O.C., and Geddes, C.D., (2019). A comparison of Lyse-It to other cellular sample preparation, bacterial lysing and DNA fragmentation technologies. PLOS ONE, 14(7): e0220102. 

4. Santaus, T., LI, S., Ladd, P., Harvey, A., Cole, S., Stine, O.C., and Geddes, C.D. (2018). Rapid sample preparation with Lyse-It® for Listeria monocytogenes and Vibrio cholerae. PLOS ONE, 13(7): e0201070.

5. Melendez, J.H., Santaus, T., Brinsley, G., Kiang, D., Mali, B., Hardick, J., Gaydos, C.A., and Geddes, C.D. (2016). Microwave-Accelerated Method for Ultra-Rapid Extraction of Neisseria gonorrhoeae DNA for Downstream Detection. Analytical BioChemistry, 510, 33-40.

6. Boyd, Mary, Tennant, Sharron, Melendez, Johan, Toema, Deanna, Galen, Jim, Geddes, Chris and Levine, Myron. (2015). Adaption of Red Blood Cell Lysis represents a fundamental breakthrough that improves Salmonella detection in Blood. J. Applied Microbiology, 118(5), 1199-1209.

7. Joshi, T., Mali., B., Geddes, C.D., Baillie, L., (2014). Extraction and Sensitive Detection of Toxins A and B from the human pathogen Clostridium difficile in 40 seconds using Microwave-Accelerated Metal-Enhanced Fluorescence, Plos One, 9,8,e104334.

8. Melendez, J.H., Huppert, J.S., Jett-Goheen, M., Hesse, E.A., Quinn, N., Gaydos, C.A. and Geddes, CD. (2013). Blind Evaluation of the Microwave-Accelerated Metal-Enhanced Fluorescence Ultrarapid and Sensitive Chlamydia Trachomatis test by use of Clinical Samples, Journal of Clinical Microbiology, 51(9), 2913-2920.

9. Zhang, Y., Agreda, P., Kelly, S., Gaydos, C., and Geddes, C. D., (2011). Development of a Microwave-Accelerated Metal-Enhanced Fluorescence 40 seconds, < 100 cfu/ml point of care assay for the detection of Chlamydia Trachomatis. IEEE Transactions on Biomedical Engineering, 58(3), 781-784.

10. Tennant, S. M., Zhang, Y., Galen, J. E., Geddes, C. D., and Levine, M.M. (2011). Ultra-fast and Sensitive detection of Non-typhoidal Salmonella using Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF), PloS One, 6, 4, e18700.

11. Aslan, K., Previte, M.J.R., Zhang, Y., Gallagher, T., Baillie, L. and Geddes, C.D. (2008). Extraction and Detection of DNA from Bacillus Anthracis Spores and the Vegetative Cells within 1 minute, Analytical Chemistry, 80, 4125-4132.

12. Wang, Y., Lee, Y.Y, Santaus, T.M., Newcomb, C.E., Liu, J., Geddes, C.D., Zhang, C., Hu, Q. and Li, Y. (2017). In Situ Enzymatic Conversion of Nannochloropsis oceanica IMET1 Biomass into Fatty Acid Methyl Esters. BioEnergy Research, 10(2), 438-448.  

Recent Book Chapters which have utilized the Lyse-It Technology

1. Santaus, T.M., Melendez, J.H., Negesse, M.Y., Harvey, A., Cyr, M., Ladd, P. and Geddes, C.D. (2017). Lyse-It: A Rapid Platform for Cellular Lysing and Tunable DNA/Protein Fragmentation in Microwave Effects on DNA and Proteins edited by Chris D. Geddes, Springer, pp 275-296, New York, USA.


1. Geddes, C.D. (2017). Lyse-It: a Single Step, Single Platform, Transformational Lysing Technology, Journal of Fluorescence, 27 (2), 417.